{ "_id": "6a213f87cd65a98ecbd29ee1", "Type": "Package", "Package": "disprofas", "Title": "Non-Parametric Dissolution Profile Analysis", "Version": "0.2.1.9000", "Authors@R": "c(\nperson(\"Pius\", \"Dahinden\", , \"pius.dahinden@tillotts.com\", role = c(\"aut\", \"cre\")),\nperson(\"Tillotts Pharma AG\", , , \"tillotts@tillotts.com\", role = c(\"cph\", \"fnd\"))\n)", "Description": "Similarity of dissolution profiles is assessed using the\nsimilarity factor f2 according to the EMA guideline (European\nMedicines Agency 2010) \"On the investigation of\nbioequivalence\". Dissolution profiles are regarded as similar\nif the f2 value is between 50 and 100. For the applicability of\nthe similarity factor f2, the variability between profiles\nneeds to be within certain limits. Often, this constraint is\nviolated. One possibility in this situation is to resample the\nmeasured profiles in order to obtain a bootstrap estimate of f2\n(Shah et al. (1998) ). Other\nalternatives are the model-independent non-parametric\nmultivariate confidence region (MCR) procedure (Tsong et al.\n(1996) ) or the T2-test for\nequivalence procedure (Hoffelder (2016)\n). Functions\nfor estimation of f1, f2, bootstrap f2, MCR / T2-test for\nequivalence procedure are implemented.", "License": "GPL (>= 2)", "URL": "https://github.com/piusdahinden/disprofas", "BugReports": "https://github.com/piusdahinden/disprofas/issues", "Encoding": "UTF-8", "Language": "en-GB", "LazyData": "true", "RoxygenNote": "7.3.2", "Repository": "https://piusdahinden.r-universe.dev", "Date/Publication": "2025-03-23 13:48:01 UTC", "RemoteUrl": "https://github.com/piusdahinden/disprofas", "RemoteRef": "HEAD", "RemoteSha": "429d6f149af74f0c75e3357102d7b289c0e4e729", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-04 09:00:52 UTC", "User": "root" }, "Author": "Pius Dahinden [aut, cre],\nTillotts Pharma AG [cph, fnd]", "Maintainer": "Pius Dahinden ", "MD5sum": "6156295f9d679a378200e71d38498e09", "_user": "piusdahinden", "_type": "src", "_file": "disprofas_0.2.1.9000.tar.gz", "_fileid": "76d3cb4b8a91f9a2b1b5001e500daa03cd963d5b5180f1676104b27e1c1099a3", "_filesize": 624771, 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formulations", "topics": [ "dip3" ] }, { "page": "dip4", "title": "Dissolution data of two different formulations", "topics": [ "dip4" ] }, { "page": "dip5", "title": "Fluid weights of drink cans", "topics": [ "dip5" ] }, { "page": "dip6", "title": "Dissolution data of a reference and a test batch", "topics": [ "dip6" ] }, { "page": "dip7", "title": "Parameter estimates of Weibull fit to individual dissolution profiles", "topics": [ "dip7" ] }, { "page": "dip8", "title": "Parameter estimates of Weibull fit to individual dissolution profiles", "topics": [ "dip8" ] }, { "page": "f1", "title": "Dissimilarity factor f1 for dissolution data", "topics": [ "f1" ] }, { "page": "f2", "title": "Similarity factor f2 for dissolution data", "topics": [ "f2" ] }, { "page": "gep_by_nera", "title": "Get points on confidence region bounds by Newton-Raphson search", "topics": [ "gep_by_nera" ] }, { "page": "get_sim_lim", "title": "Similarity limit", "topics": [ "get_sim_lim" ] }, { "page": "get_T2_one", 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